IMMUNOLOGY2026™ Conference Recordings For Attendees-Functional Dynamics of Cytotoxic CD4+ T cells in Acute and Chronic Viral Infections

Functional Dynamics of Cytotoxic CD4+ T cells in Acute and Chronic Viral Infections

Video Transcription

Video Summary

The talk described research on cytotoxic CD4 T cells during acute and chronic LCMV viral infection. Using adoptive transfer and cytotoxicity assays, the team found CD4 T cells can directly kill target cells in both settings, but this function is reduced during chronic infection due to T cell exhaustion. Perforin was shown to contribute partially to killing. A bone marrow chimera model suggested CD4 T cells may eliminate virally infected CD8alpha dendritic cells, especially in chronic infection, potentially improving antigen presentation and T cell responses.

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Date April 19, 2026 9:00 AM - 9:15 AM

Room 104AB

Session CD4+ T Cell and B Cell Mediated Immunity against Viruses

Speaker Prakash Sahoo

Track Viral Immunology (VIR)

Year 2026

Keywords

cytotoxic CD4 T cells

LCMV infection

T cell exhaustion

perforin-mediated killing

CD8alpha dendritic cells

April 19, 2026 9:00 AM - 9:15 AM

104AB

CD4+ T Cell and B Cell Mediated Immunity against Viruses

Prakash Sahoo

Viral Immunology (VIR)

2026