IMMUNOLOGY2026™ Conference Recordings For Attendees-Functional dichotomy of GC-Derived Memory B Cells in Lupus: A Role for FCRL5+ MBCs in ASC Differentiation

Functional dichotomy of GC-Derived Memory B Cells in Lupus: A Role for FCRL5+ MBCs in ASC Differentiation

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Video Summary

The talk examined the functional diversity of germinal center-derived memory B cells in lupus. Using mouse models and single-cell profiling, the speaker identified two key memory subsets: one that rapidly differentiates into antibody-secreting cells and produces autoantibodies, and another that can recycle back into germinal centers, potentially driving epitope spreading and chronic autoimmunity. The study also highlighted complement receptor 2 (C21) as a marker of memory B cells with high ASC potential and a possible therapeutic target, since blocking it reduced germinal center responses and shifted cells toward a less pathogenic state.

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Date April 16, 2026 9:00 AM - 9:15 AM

Room 156

Session Targeting B Cells and Innate Immune Functions in Autoimmunity

Speaker Ajitanuj Rattan

Track Therapeutic Approaches to Autoimmunity (THER)

Year 2026

Keywords

lupus

memory B cells

germinal centers

autoantibodies

complement receptor 2

April 16, 2026 9:00 AM - 9:15 AM

156

Targeting B Cells and Innate Immune Functions in Autoimmunity

Ajitanuj Rattan

Therapeutic Approaches to Autoimmunity (THER)

2026