IMMUNOLOGY2026™ Conference Recordings For Attendees-GC-independent B cells contribute to durable humoral responses and protection in mice

GC-independent B cells contribute to durable humoral responses and protection in mice

Video Transcription

Video Summary

The speaker studied germinal center-independent memory B cells in mice to understand whether they can generate durable antibody responses and protection. Using knockout mouse models, single-cell RNA sequencing, and newly identified surface markers CD148 and CD150, they distinguished germinal center-derived from extrafollicular memory B cells. They found some GC-independent memory cells are T cell-dependent, show low somatic hypermutation, and resemble human extrafollicular B cells. Vaccination and infection experiments showed these cells can mediate antibody-based protection against both matched and mismatched influenza challenges, and transferred memory B cells alone were protective.

Meta Tag

Date April 16, 2026 12:45 PM - 1:00 PM

Room 157

Session Homeostasis

Speaker Elif Cakan

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

germinal center-independent memory B cells

CD148 and CD150 markers

extrafollicular B cells

influenza antibody protection

single-cell RNA sequencing

April 16, 2026 12:45 PM - 1:00 PM

157

Homeostasis

Elif Cakan

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026