IMMUNOLOGY2026™ Conference Recordings For Attendees-GLUT1 in Memory CD4+ T-cells Correlates with Sustained Antibody Responses and Polyfunctionality Post-RSV Vaccination in Immunocompromised Individuals

GLUT1 in Memory CD4+ T-cells Correlates with Sustained Antibody Responses and Polyfunctionality Post-RSV Vaccination in Immunocompromised Individuals

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Video Summary

Nirvani Jaram presented a Johns Hopkins study on RSV vaccination in immunocompromised people, mainly solid organ transplant recipients and patients with autoimmune disease. Compared with healthy adults, these patients showed weaker antibody and neutralizing responses after vaccination. Her work found that the glucose transporter GLUT1 on RSV-specific memory CD4 T cells strongly correlated with cytokine production, polyfunctionality, and antibody titers, especially around 12 weeks post-vaccination. These associations were not seen at baseline. The findings suggest T-cell metabolic fitness may help predict vaccine responses and could guide better vaccination strategies for immunocompromised individuals.

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Date April 16, 2026 3:45 PM - 4:00 PM

Room 102

Session Innovations Targeting Adaptive Immune Mechanisms against Viral Pathogens

Speaker Nirvani Jairam

Track Vaccines and Immunotherapy (VAC)

Year 2026

Keywords

RSV vaccination

immunocompromised patients

solid organ transplant recipients

GLUT1

T-cell metabolic fitness

April 16, 2026 3:45 PM - 4:00 PM

102

Innovations Targeting Adaptive Immune Mechanisms against Viral Pathogens

Nirvani Jairam

Vaccines and Immunotherapy (VAC)

2026