IMMUNOLOGY2026™ Conference Recordings For Attendees-Germline-encoded recognition underlies development of convergent antibodies in humans

Germline-encoded recognition underlies development of convergent antibodies in humans

Video Transcription

Video Summary

The speaker describes research on peanut-specific antibodies and how humans can generate highly similar, high-affinity IgG antibodies to peanut allergens. Using monoclonal antibodies from peanut-allergic patients, the lab found structurally convergent antibodies that were already present in germline form, not created by somatic mutation. They also showed somatic hypermutation can expand cross-reactivity to another peanut allergen, Ara h 6. Population analyses suggested these responses are broadly possible, with most people carrying the needed genetic alleles. Serum studies showed nearly all tested allergic individuals, and most infants after early peanut introduction, recognized the same dominant epitope.

Meta Tag

Date April 18, 2026 10:00 AM - 10:15 AM

Room 151

Session Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

Speaker Orlee Marini-Rapoport

Track Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

Year 2026

Keywords

peanut-specific antibodies

IgG antibodies

somatic hypermutation

Ara h 6

dominant epitope

April 18, 2026 10:00 AM - 10:15 AM

151

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

Orlee Marini-Rapoport

2026