IMMUNOLOGY2026™ Conference Recordings For Attendees-Glucocorticoid signaling shapes the differentiation of tumor-infiltrating CD8+ T cells through TXNIP-dependent metabolic rewiring

Glucocorticoid signaling shapes the differentiation of tumor-infiltrating CD8+ T cells through TXNIP-dependent metabolic rewiring

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Video Summary

The talk showed that glucocorticoid receptor (GR) signaling in tumor-infiltrating CD8+ T cells drives them toward dysfunctional, immune checkpoint–responsive states and away from effective anti-tumor states. Single-cell RNA-seq revealed two main trajectories: one associated with proliferation/dysfunction and poor response to checkpoint blockade, and another linked to effector and tissue-resident memory-like function. GR knockout cells preferentially followed the effector trajectory and controlled tumors better. Metabolic analysis showed the effector trajectory had higher glycolysis, while glucocorticoid treatment suppressed glycolysis and glucose uptake in wild-type but not GR-deficient T cells. TSNIP emerged as a key GR target linking GR signaling to reduced glycolysis. TSNIP knockout improved tumor control and T-cell effector function, phenocopying GR deficiency. Overall, GR promotes CD8+ T-cell dysfunction in tumors through TSNIP-mediated suppression of glycolysis.

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Date April 15, 2026 2:45 PM - 3:00 PM

Room 156

Session T Cells in Cancer I

Speaker Dandan Yang

Track Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

Year 2026

Keywords

glucocorticoid receptor

CD8+ T cells

tumor infiltration

TSNIP

glycolysis

April 15, 2026 2:45 PM - 3:00 PM

156

T Cells in Cancer I

Dandan Yang

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

2026