IMMUNOLOGY2026™ Conference Recordings For Attendees-High-Throughput Proteomic Profiling of Hepatocyte Response to Oncologic Compounds for Toxicity and Immune Risk Prediction in Drug Development

High-Throughput Proteomic Profiling of Hepatocyte Response to Oncologic Compounds for Toxicity and Immune Risk Prediction in Drug Development

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Video Summary

Nicole Paul from Nomic Bio presented a high-throughput proteomics platform for profiling secreted proteins to distinguish immune modulation from toxicity in drug discovery. Using the Omni1000/NLISA system, Nomic can measure 1,000 proteins across 10,000 samples with high sensitivity. In large screens of hepatocytes, microglia, and cardiomyocytes, proteomics identified inflammatory suppression, cytotoxicity, and organ-specific toxicity, often earlier than cell painting. The approach predicted clinical toxicity in 80% of cases and was applied to consortium studies and organoid models, showing promise for mechanistic insight and safety prediction before clinical development.

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Date April 15, 2026 3:15 PM - 3:30 PM

Room 151

Session Immunological -omics Analysis

Speaker Nicole Paul

Track Computational and Systems Immunology (COMP)

Year 2026

Keywords

high-throughput proteomics

secreted proteins

drug toxicity prediction

Omni1000 NLISA

immune modulation

April 15, 2026 3:15 PM - 3:30 PM

151

Immunological -omics Analysis

Nicole Paul

Computational and Systems Immunology (COMP)

2026