IMMUNOLOGY2026™ Conference Recordings For Attendees-Highly dynamic dural sinuses support meningeal immunity

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Video Summary

Researchers investigated the dural venous sinuses, especially the sagittal sinus, long thought to be passive drainage vessels. They found that the sinuses are highly specialized, immunologically active structures that help regulate intracranial fluid pressure and support immune surveillance. In mice and humans, the sagittal sinus has fenestrated endothelial cells that allow exchange of fluid, antigens, and immune cells between the bloodstream and the perisinus space. The sinus is split into upper and lower compartments and can be compressed to alter intracranial pressure, showing its role in fluid egress. Using imaging, electron microscopy, and single-cell RNA sequencing, the team identified dynamic sinus endothelial cells that form transient openings and boundary “ruffles.” These structures depend on RAMP2 signaling and support leukocyte trafficking. During viral infection, these dynamics increase, and disrupting them impairs viral control, demonstrating that the sagittal sinus is an active site for local antiviral immunity.

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Date April 18, 2026 10:45 AM - 10:57 AM

Room 104AB

Session Immunity at CNS Barriers and Borders

Speaker Kelly Monaghan

Track Neuroimmunology (NEUR)

Year 2026

Keywords

dural venous sinuses

sagittal sinus

intracranial pressure

immune surveillance

leukocyte trafficking

April 18, 2026 10:45 AM - 10:57 AM

104AB

Immunity at CNS Barriers and Borders

Kelly Monaghan

Neuroimmunology (NEUR)

2026