IMMUNOLOGY2026™ Conference Recordings For Attendees-Homologous MHC Antigens Induce cDC1-like Differentiation from Monocyte-Derived Dendritic Cells

Homologous MHC Antigens Induce cDC1-like Differentiation from Monocyte-Derived Dendritic Cells

Video Transcription

Video Summary

The talk showed that homologous MHC class I and II epitopes can drive monocyte-derived dendritic cells toward a CDC1-like, type 1–polarizing state. Single-cell RNA-seq and flow cytometry revealed increased CDC1 markers and pro-inflammatory pathways, alongside reduced anti-inflammatory signaling. Mechanistically, homologous epitopes inhibited the mTORC1 pathway by blocking lysosomal recruitment of mTORC1, confirmed in mouse and human cells. Analysis of patient dendritic cell vaccine products showed similar CDC1-like shifts and mTORC1 suppression, suggesting translational relevance for cancer immunotherapy. The work reframes antigen as a factor that shapes dendritic cell fate, not just T cell responses.

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Date April 17, 2026 8:30 AM - 8:45 AM

Room 156

Session Mechanisms of Innate Immunity

Speaker Sharon Bright Amanya

Track Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

Year 2026

Keywords

MHC class I and II epitopes

dendritic cell polarization

CDC1-like state

mTORC1 inhibition

cancer immunotherapy

April 17, 2026 8:30 AM - 8:45 AM

156

Mechanisms of Innate Immunity

Sharon Bright Amanya

Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

2026