IMMUNOLOGY2026™ Conference Recordings For Attendees-Host HLA Allelic Variation Shapes Risk of Severe SARS-CoV-2 Infection and Long COVID

Host HLA Allelic Variation Shapes Risk of Severe SARS-CoV-2 Infection and Long COVID

Video Transcription

Video Summary

Grace Kim, an MD-PhD student, discussed how COVID-19 severity and long COVID vary widely and may be influenced by HLA genetics. Using the NIH All of Us dataset and HLA imputation from microarray data in over 113,000 participants, her team compared COVID-negative controls with participants who had COVID pneumonia or long COVID. They identified 14 HLA alleles linked to either protection or risk. Class I alleles were more associated with acute viral control, while some class II alleles appeared tied to long COVID, suggesting autoimmune-like mechanisms. The study also noted sex and ancestry-related differences and plans further multivariate analysis.

Meta Tag

Date April 17, 2026 1:00 PM - 1:15 PM

Room 205

Session Interrogation of Chronic Immunity and Interventional Approaches

Speaker Grace Kim

Track Translational and Interventional Immunology (TI)

Year 2026

Keywords

COVID-19 severity

long COVID

HLA genetics

NIH All of Us

HLA alleles

April 17, 2026 1:00 PM - 1:15 PM

205

Interrogation of Chronic Immunity and Interventional Approaches

Grace Kim

Translational and Interventional Immunology (TI)

2026