IMMUNOLOGY2026™ Conference Recordings For Attendees-Host Lipid and Mitochondrial Metabolism Networks as Functional Targets for Novel Antimicrobials against Intracellular Bacteria

Host Lipid and Mitochondrial Metabolism Networks as Functional Targets for Novel Antimicrobials against Intracellular Bacteria

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Video Summary

The speaker discussed how <strong>Francisella tularensis</strong>, a dangerous intracellular bacterium causing tularemia, manipulates host <strong>lipid metabolism</strong> to aid infection. Francisella lipids increase <strong>lipid droplet formation</strong>, boost <strong>mitochondrial respiration</strong>, and enhance bacterial uptake and replication in macrophages. The team found that the host regulator <strong>PGC1-alpha</strong> is induced by infection and bacterial lipids, and blocking it can strongly reduce bacterial growth. Overall, the talk proposed that Francisella repurposes host lipids and energy pathways to maintain a favorable environment while suppressing inflammation, suggesting these metabolic pathways could be targets for new treatments.

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Date April 17, 2026 8:15 AM - 8:30 AM

Room 156

Session Mechanisms of Innate Immunity

Speaker Catharine Bosio

Track Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

Year 2026

Keywords

Francisella tularensis

tularemia

lipid metabolism

PGC1-alpha

macrophage infection

April 17, 2026 8:15 AM - 8:30 AM

156

Mechanisms of Innate Immunity

Catharine Bosio

Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

2026