IMMUNOLOGY2026™ Conference Recordings For Attendees-ICAM-1 Adhesion Molecules Facilitate Immune Cell Docking at the Cribriform Plate Perineural Microenvironment in Aging

ICAM-1 Adhesion Molecules Facilitate Immune Cell Docking at the Cribriform Plate Perineural Microenvironment in Aging

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Video Summary

The speaker studied how aging affects the cribriform plate, a key drainage site for cerebrospinal fluid and immune cells. In aged mice, she found thicker extracellular matrix around olfactory nerve bundles, more immune cell accumulation, and increased ICAM-1 expression on the nerve epineurium. Light-sheet imaging suggested multiple ICAM-1–positive cell types. Human cribriform plate samples also showed higher perineural ICAM-1 with age. The data suggest ICAM-1 may anchor myeloid cells, promoting inflammation, nerve damage, and reduced drainage, which could contribute to cognitive decline or loss of smell.

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Date April 18, 2026 10:09 AM - 10:21 AM

Room 104AB

Session Immunity at CNS Barriers and Borders

Speaker Jenna Port

Track Neuroimmunology (NEUR)

Year 2026

Keywords

cribriform plate

ICAM-1

aging

cerebrospinal fluid drainage

immune cell accumulation

April 18, 2026 10:09 AM - 10:21 AM

104AB

Immunity at CNS Barriers and Borders

Jenna Port

Neuroimmunology (NEUR)

2026