IMMUNOLOGY2026™ Conference Recordings For Attendees-IL-1 signaling directs the prioritization of inflammatory sites in a model of post-operative pulmonary infection

IL-1 signaling directs the prioritization of inflammatory sites in a model of post-operative pulmonary infection

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Video Summary

Researchers studied why surgical wounds heal poorly when patients develop a lung infection after surgery. In mouse models, postoperative pulmonary infection with bacteria delayed wound closure and reduced immune cell recruitment to the wound, especially neutrophils. The defect was linked to early suppression of wound chemokines CCL2 and CXCL1, preceded by a drop in IL-1β. Restoring IL-1β, or directly adding CCL2 and CXCL1, increased wound cellularity and improved healing. Blocking IL-1 signaling with anakinra mimicked the infection effect, while mice lacking IL-1 receptor antagonist (IL-1RA) showed better wound immune responses. However, these wound improvements came at a cost: lung bacterial clearance worsened. The findings suggest that during lung infection, the body may induce IL-1RA to protect the lung, but this suppresses distant wound healing by limiting neutrophil recruitment.

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Date April 18, 2026 1:57 PM - 2:09 PM

Room 153AB

Session Pathophysiology of Cytokines and Chemokines

Speaker Meredith Crane

Track Cytokines and Chemokines and their Receptors (CCR)

Year 2026

Keywords

surgical wound healing

postoperative lung infection

IL-1β suppression

neutrophil recruitment

CCL2 CXCL1 chemokines

April 18, 2026 1:57 PM - 2:09 PM

153AB

Pathophysiology of Cytokines and Chemokines

Meredith Crane

Cytokines and Chemokines and their Receptors (CCR)

2026