IMMUNOLOGY2026™ Conference Recordings For Attendees-IL-15 induces durable resident memory T cell formation and function following genetically attenuated Plasmodium vaccination in mice

IL-15 induces durable resident memory T cell formation and function following genetically attenuated Plasmodium vaccination in mice

Back to course

Video Transcription

Video Summary

The speaker described malaria vaccine research targeting Plasmodium’s liver stage to prevent progression to the blood stage. Because whole sporozoite GAP vaccines are effective but expensive, the lab tested whether interleukin-15 complex could boost immunity and reduce needed doses. In mice, IL-15 complex increased antigen-experienced T cells, liver resident memory T cells, IFN-gamma-producing T cells, and Plasmodium-specific antibodies. It also lowered liver parasite burden and improved sterilizing immunity from 25% to 85% after challenge. Overall, IL-15 complex appears to enhance TRM formation and vaccine efficacy, offering a promising host-targeted strategy for malaria vaccination.

Meta Tag

Date April 19, 2026 10:15 AM - 10:30 AM

Room 102

Session Innovations in Vaccine Adjuvants and Immune Modulation

Speaker Rizwan Mahmud

Track Vaccines and Immunotherapy (VAC)

Year 2026

Keywords

malaria vaccine

Plasmodium liver stage

interleukin-15 complex

resident memory T cells

sterilizing immunity

April 19, 2026 10:15 AM - 10:30 AM

102

Innovations in Vaccine Adjuvants and Immune Modulation

Rizwan Mahmud

Vaccines and Immunotherapy (VAC)

2026