IMMUNOLOGY2026™ Conference Recordings For Attendees-IgA is necessary and sufficient to protect against norovirus infection

IgA is necessary and sufficient to protect against norovirus infection

Video Transcription

Video Summary

Researchers studied murine norovirus to understand why human norovirus vaccines have been ineffective. They found that persistent infection is key for generating strong intestinal immune responses, especially dimeric IgA produced by plasma cells. IgA levels rose with longer infection, became neutralizing, and were necessary to control chronic infection and prevent reinfection. After six months, protection waned as antibodies declined. Finally, delivering anti-norovirus dimeric IgA with mRNA lipid nanoparticles protected mice from infection, suggesting a possible therapeutic or vaccine strategy for norovirus, especially with mucosal boosting.

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Date April 19, 2026 8:00 AM - 8:15 AM

Room 104AB

Session CD4+ T Cell and B Cell Mediated Immunity against Viruses

Speaker Arya Ökten

Track Viral Immunology (VIR)

Year 2026

Keywords

murine norovirus

dimeric IgA

persistent infection

intestinal immune response

mRNA lipid nanoparticles

April 19, 2026 8:00 AM - 8:15 AM

104AB

CD4+ T Cell and B Cell Mediated Immunity against Viruses

Arya Ökten

Viral Immunology (VIR)

2026