IMMUNOLOGY2026™ Conference Recordings For Attendees-IgM antibodies and B cells are early responders during acute secondary viral infections and contribute to protection from severe disease

IgM antibodies and B cells are early responders during acute secondary viral infections and contribute to protection from severe disease

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Video Summary

The speaker studies dengue and Zika antibodies, focusing on IgM, a usually minor and short-lived antibody class. She discovered a highly potent Zika-neutralizing IgM and then tested IgM’s role in dengue infections using pediatric patient samples. In secondary dengue, IgM contributed substantially to virus neutralization and was associated with milder disease. Unlike primary infection, secondary IgM was broader, cross-neutralizing multiple dengue serotypes, suggesting a memory-like response. She also found distinct dengue-specific IgM B-cell subsets with different trajectories over time, showing IgM plays an important, previously underappreciated role in protection.

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Date April 19, 2026 8:30 AM - 8:45 AM

Room 104AB

Session CD4+ T Cell and B Cell Mediated Immunity against Viruses

Speaker Tulika Singh

Track Viral Immunology (VIR)

Year 2026

Keywords

IgM antibodies

dengue neutralization

Zika virus

secondary dengue infection

B-cell subsets

April 19, 2026 8:30 AM - 8:45 AM

104AB

CD4+ T Cell and B Cell Mediated Immunity against Viruses

Tulika Singh

Viral Immunology (VIR)

2026