IMMUNOLOGY2026™ Conference Recordings For Attendees-Immune resilience after pediatric cancer treatment

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Video Summary

The talk examined long-term immune recovery in pediatric cancer survivors, focusing on acute lymphoblastic leukemia (ALL) and Hodgkin’s lymphoma patients from the St. Jude Lifetime Cohort. Using longitudinal serum samples and a proteomics platform measuring about 7,000 proteins, the team asked whether survivors return to a normal “basal” immune state or develop a new one after treatment. They found that higher chronic health burden was linked to clear immune dysregulation: increased inflammatory and MAPK/JAK-STAT signaling, reduced chemotaxis, humoral immunity, complement/coagulation, and broader adaptive immune dysfunction. These patterns were seen in both ALL and Hodgkin’s lymphoma survivors, though with some disease-specific differences. The findings suggest that late effects in survivors may reflect persistent immune imbalance and reduced immune resilience. The team is now validating these markers in larger cohorts and expanding to single-cell, T-cell repertoire, and flow cytometry studies to better map immune recovery over time.

Meta Tag

Date April 15, 2026 4:15 PM - 4:30 PM

Room 157

Session Orchestration of the Adaptive Immune Response

Speaker Smrithi Sugumaran Menon

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

pediatric cancer survivors

immune recovery

acute lymphoblastic leukemia

Hodgkin’s lymphoma

immune dysregulation

April 15, 2026 4:15 PM - 4:30 PM

157

Orchestration of the Adaptive Immune Response

Smrithi Sugumaran Menon

Immune Mechanisms of Human Disease (HUM)

2026