IMMUNOLOGY2026™ Conference Recordings For Attendees-Inborn errors of T cell topographic memory underlie organ-selective infectious diseases

Inborn errors of T cell topographic memory underlie organ-selective infectious diseases

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Video Summary

Researchers studied topographic memory in T cells, the tissue “homing” program that directs cells to specific organs like skin or gut. Using human genetics, they identified biallelic ITGAL mutations causing loss of LFA-1, leading to a strikingly skin-restricted immunodeficiency. Patients had reduced skin-homing T cells in skin and their accumulation in blood, causing warts and skin cancers but few infections elsewhere. The findings show that some memory T cells depend uniquely on LFA-1 to reach skin, proving that defective tissue homing can cause organ-specific immune disease.

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Date April 17, 2026 10:15 AM - 10:30 AM

Room 102

Session Lymphocyte and Innate Leukocyte Mastery of Heat, Migration, and Inflammation

Speaker Ahmad Yatim

Track Cellular Adhesion, Migration, and Inflammation (CAM)

Year 2026

Keywords

topographic memory

T cell homing

ITGAL mutations

LFA-1 deficiency

skin-restricted immunodeficiency

April 17, 2026 10:15 AM - 10:30 AM

102

Lymphocyte and Innate Leukocyte Mastery of Heat, Migration, and Inflammation

Ahmad Yatim

Cellular Adhesion, Migration, and Inflammation (CAM)

2026