IMMUNOLOGY2026™ Conference Recordings For Attendees-Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson's Disease

Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson's Disease

Video Transcription

Video Summary

The speaker discusses inflammation in Parkinson’s disease, emphasizing evidence that alpha-synuclein-reactive T cells appear early, especially in REM sleep behavior disorder, a prodromal stage. Using blood, CSF, and single-cell profiling, the team found increased CSF cells and a rise in a unique microglia-like CSF macrophage population in early Parkinson’s, with strong inflammatory signaling such as TNF and JAK-STAT activation. These changes were opposite to multiple sclerosis. Similar immune signatures were seen in Parkinson’s brain tissue, dura, and gut, suggesting a coordinated inflammatory progression from peripheral tissues to the brain.

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Date April 18, 2026 12:30 PM - 2:30 PM

Room 104C

Session Autoimmunity, Neurodegeneration and Aging

Speaker Yoshiaki Yasumizu

Track Basic Autoimmunity (BA)

Year 2026

Keywords

Parkinson’s disease

alpha-synuclein-reactive T cells

REM sleep behavior disorder

microglia-like CSF macrophages

inflammatory signaling

April 18, 2026 12:30 PM - 2:30 PM

104C

Autoimmunity, Neurodegeneration and Aging

Yoshiaki Yasumizu

Basic Autoimmunity (BA)

2026