IMMUNOLOGY2026™ Conference Recordings For Attendees-Inflammatory hematopoiesis drives intestinal inflammation and is modulated by anti-TNF therapy

Inflammatory hematopoiesis drives intestinal inflammation and is modulated by anti-TNF therapy

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Video Summary

The speaker presented research on how inflammatory hematopoiesis may worsen Crohn’s disease. Using enriched CD34+ cells from blood and 10x multiome profiling in healthy donors and Crohn’s patients, the team found that early hematopoietic progenitors in Crohn’s are reprogrammed toward inflammatory, metabolic, and antigen-presentation programs, driven by TF networks such as NF-kB, AP-1, and CEBPβ. These progenitor programs were also reflected in monocytes, suggesting inflammatory memory is passed from bone marrow precursors to mature immune cells. In a DSS colitis mouse model, gut inflammation altered bone marrow progenitors, increased inflammatory motifs, and produced myeloid cells with enhanced cytokine production and migration. Bone marrow from DSS-experienced mice worsened colitis when transferred into recipients. Importantly, anti-TNF therapy partially reset these progenitor programs, showing the changes are reversible. Overall, HSPCs act as a treatment-responsive inflammatory reservoir in IBD.

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Date April 16, 2026 5:00 PM - 5:15 PM

Room 104AB

Session Bone Marrow Hematopoiesis

Speaker Jin-Gyu Cheong

Track Hematopoiesis and Immune System Development (HEM)

Year 2026

Keywords

Crohn’s disease

inflammatory hematopoiesis

CD34+ progenitor cells

NF-kB AP-1 CEBPβ

anti-TNF therapy

April 16, 2026 5:00 PM - 5:15 PM

104AB

Bone Marrow Hematopoiesis

Jin-Gyu Cheong

Hematopoiesis and Immune System Development (HEM)

2026