IMMUNOLOGY2026™ Conference Recordings For Attendees-Inflammatory monocyte recruitment depends on adventitial fibroblast-derived CCL2 following influenza A virus infection

Inflammatory monocyte recruitment depends on adventitial fibroblast-derived CCL2 following influenza A virus infection

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Video Summary

The speaker studies how lung fibroblasts shape influenza severity. While antivirals and vaccines help, severe disease is often driven by excessive immune inflammation. They found that adventitial fibroblasts, unlike alveolar or peribronchial fibroblasts, are more strongly activated during infection and produce CCL2. This CCL2 recruits inflammatory monocytes into lung tissue, promoting damage and lowering oxygen levels. In fibroblast-specific CCL2 knockout mice, monocyte recruitment dropped and lung function improved. The work suggests that targeting activated adventitial fibroblasts or their CCL2 signaling could reduce harmful inflammation and prevent severe post-influenza disease.

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Date April 17, 2026 8:45 AM - 9:00 AM

Room 104AB

Session Cytokines and Inflammation in Antiviral Immunity

Speaker Shally Saini

Track Viral Immunology (VIR)

Year 2026

Keywords

influenza severity

lung fibroblasts

adventitial fibroblasts

CCL2 signaling

monocyte recruitment

April 17, 2026 8:45 AM - 9:00 AM

104AB

Cytokines and Inflammation in Antiviral Immunity

Shally Saini

Viral Immunology (VIR)

2026