IMMUNOLOGY2026™ Conference Recordings For Attendees-Inherited C5aR2 deficiency leads to uncontrolled inflammatory T cell responses and autoinflammatory disease

Inherited C5aR2 deficiency leads to uncontrolled inflammatory T cell responses and autoinflammatory disease

Video Transcription

Video Summary

The talk described how a C5a receptor 2 (C5AR2) mutation may cause autoinflammatory disease by failing to restrain inflammatory T cell responses. The speaker explained that complement also acts inside cells, especially in CD4 T cells, where C5a signaling promotes Th1 inflammation. In a patient with fever, joint swelling, and skin rashes, IL-10 receptor function was normal, but the C5AR2 variant blocked ligand binding and downstream signaling. Patient T cells showed loss of naive/central memory cells and a strong interferon-gamma–producing effector profile. The group also implicated carboxypeptidase M in generating the C5a form that activates C5AR2.

Meta Tag

Date April 19, 2026 10:45 AM - 11:00 AM

Room 153 AB

Session Primary Immune Deficiency and Immune Dysregulation

Speaker Erin West

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

C5AR2 mutation

autoinflammatory disease

C5a signaling

CD4 T cells

Th1 inflammation

April 19, 2026 10:45 AM - 11:00 AM

153 AB

Primary Immune Deficiency and Immune Dysregulation

Erin West

Immune Mechanisms of Human Disease (HUM)

2026