IMMUNOLOGY2026™ Conference Recordings For Attendees-Inhibition of Glutamine metabolism is essential in decreasing the hallmarks of Atopic Dermatitis pathogenesis.

Inhibition of Glutamine metabolism is essential in decreasing the hallmarks of Atopic Dermatitis pathogenesis.

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Video Summary

The speaker presented PhD research on atopic dermatitis (AD), a common chronic inflammatory skin disease caused by skin barrier damage and allergic sensitization. Building on prior asthma work, the lab found that allergen stimulation increased glutamine-derived alpha-ketoglutarate, which was reduced by inhibiting GLS-1 with CBA39. In an AD mouse model induced with MC903, CBA39 improved skin appearance, reduced ear thickness, and decreased immune cell infiltration. It specifically lowered TFH2 cells, IgE, and IgG1 while increasing regulatory T follicular cells, suggesting immune suppression. Rag-knockout mice showed no benefit from CBA39, indicating the effect depends on T and B cells. The study also linked alpha-ketoglutarate to HIF-1 alpha regulation: blocking PHD with roxatastat stabilized HIF-1 alpha and similarly reduced AD pathology. The work suggests a glutamine–alpha-ketoglutarate–HIF-1 alpha pathway, possibly involving macrophages and T cells, as a new target for AD treatment.

Meta Tag

Date April 18, 2026 10:30 AM - 10:45 AM

Room 151

Session Immediate Hypersensitivity

Speaker Araba Abaidoo-Myles

Track Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

Year 2026

Keywords

atopic dermatitis

glutamine metabolism

alpha-ketoglutarate

HIF-1 alpha

immune regulation

April 18, 2026 10:30 AM - 10:45 AM

151

Immediate Hypersensitivity

Araba Abaidoo-Myles

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

2026