IMMUNOLOGY2026™ Conference Recordings For Attendees-Innate lymphocyte regulation of physiology & tolerance in the intestine

Video Transcription

Video Summary

The speaker reviewed how gut immune tolerance was first linked to inflammatory bowel disease through early knockout mouse studies and the microbiota’s role in triggering inflammation. The talk then focused on a newer paradigm: innate lymphoid cells, especially RORγt+ ILC3s that act as antigen-presenting cells in the intestine. These cells use MHC class II to restrain microbiota-specific T cells and promote a specialized IL-10–producing regulatory T-cell population. The speaker described evidence that microbial sensing by these cells occurs through STING, which drives their migration to lymph nodes and supports tolerance. They also showed that B7 co-stimulation unexpectedly suppresses this regulatory pathway, while CTLA-4 Ig can enhance gut regulatory T cells in certain models. However, this effect depends on the presence of RORγt+ antigen-presenting cells, helping explain why CTLA-4 Ig failed in inflammatory bowel disease trials. The talk ended with future directions for innate lymphocyte research in cancer, inflammation, and therapy.

Meta Tag

Date April 17, 2026 12:45 PM - 2:15 PM

Room 151

Session Novel Insights into Innate Lymphocyte Research: Challenges and Opportunities Across Human Health and Disease, Sponsored by NCI, NIH

Speaker Gregory Sonnenberg

Track Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

Year 2026

Keywords

gut immune tolerance

inflammatory bowel disease

RORγt+ ILC3

MHC class II

STING signaling

CTLA-4 Ig

April 17, 2026 12:45 PM - 2:15 PM

151

Novel Insights into Innate Lymphocyte Research: Challenges and Opportunities Across Human Health and Disease, Sponsored by NCI, NIH

Gregory Sonnenberg

Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

2026