IMMUNOLOGY2026™ Conference Recordings For Attendees-Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity

Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity

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Video Summary

Teresa presented research on multiple sclerosis showing how diet and the gut microbiome interact to influence CNS autoimmunity. Using mouse EAE models, her team found that high dietary tryptophan and colonization with <em>L. reuteri</em> worsened disease and increased IL-17-producing gamma delta T cells. Multi-omics analysis of microbiome and serum metabolites highlighted tryptophan-related metabolites, especially indoles and p-cresol, as key disease-associated factors. Testing these metabolites directly showed they exacerbated EAE and phenocopied the effects of <em>L. reuteri</em>, supporting multi-omics as a tool for identifying disease-modulating pathways.

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Date April 18, 2026 2:00 PM - 2:15 PM

Room 153C

Session Emerging Topics in Mucosal Immunology

Speaker Theresa Montgomery

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

multiple sclerosis

gut microbiome

tryptophan metabolites

EAE mouse model

IL-17 gamma delta T cells

April 18, 2026 2:00 PM - 2:15 PM

153C

Emerging Topics in Mucosal Immunology

Theresa Montgomery

Mucosal And Regional Immunology (MUC)

2026