IMMUNOLOGY2026™ Conference Recordings For Attendees-Integrin agonists: new tools for organoids

Video Transcription

Video Summary

Tim Springer reviewed the discovery and biology of integrins, beginning with early work on leukocyte adhesion molecules such as LFA-1 and ICAM-1, and how these findings explained T cell contact, leukocyte trafficking, and immune sensitivity. He described how integrins are essential for leukocyte rolling, firm adhesion, and tissue entry, and how defects in these molecules cause immune disease and recurrent infections. Springer then explained integrin structure, conformational states, and how actin-driven force and ligand binding produce ultrasensitive activation. He emphasized that integrins do not simply adhere cells, but also transmit signals that regulate survival, growth, and differentiation.<br /><br />The talk then shifted to organoids. Springer showed that integrin agonists or inhibitory antibodies can strongly alter organoid polarity, survival, and growth. He highlighted bacterial invasin as a powerful integrin-binding tool that can promote organoid formation and may be useful for tissue engineering. Finally, he proposed developing new integrin-specific agonists covalently attached to hydrogels to improve 3D-printed, organ-like tissues for transplantation.

Meta Tag

Date April 18, 2026 4:21 PM - 4:49 PM

Room Ballroom

Session President's Symposium: Going Places: The Multi-Step Adhesion Cascade - 35 Years and Counting

Speaker Timothy Springer

Track Cellular Adhesion, Migration, and Inflammation (CAM)

Year 2026

Keywords

integrins

leukocyte adhesion

immune trafficking

LFA-1

ICAM-1

organoids

tissue engineering

April 18, 2026 4:21 PM - 4:49 PM

Ballroom

President's Symposium: Going Places: The Multi-Step Adhesion Cascade - 35 Years and Counting

Timothy Springer

Cellular Adhesion, Migration, and Inflammation (CAM)

2026