IMMUNOLOGY2026™ Conference Recordings For Attendees-Integrin-mediated entry and fibroblast-supported retention in memory B cell residency in allergic lungs

Integrin-mediated entry and fibroblast-supported retention in memory B cell residency in allergic lungs

Video Transcription

Video Summary

The talk examined how integrins help memory B cells enter allergic lungs and form BALT-like lymphoid aggregates that sustain IgE responses in asthma. Using a mouse model sensitized with ragweed plus OVA, the speaker showed that lung-resident memory B cells express higher levels of integrin α4 (CD49D/VLA-4) and αL (CD11A/LFA-1) than circulating B cells. Blocking either integrin alone only modestly reduced lung B cell entry, but blocking both significantly decreased B cells in lung tissue and increased them in the vasculature, indicating compensatory roles in endothelial trafficking. This blockade also reduced OVA-specific IgE in airways. Antibodies against endothelial ligands VCAM1 and ICAM1 produced similar, though still preliminary, reductions and appeared to selectively limit memory B cell recruitment without strongly affecting naive B cells. Overall, the work suggests integrin-adhesion interactions are important for lung memory B cell accumulation and may be a therapeutic target in allergic asthma.

Meta Tag

Date April 17, 2026 10:30 AM - 10:45 AM

Room 102

Session Lymphocyte and Innate Leukocyte Mastery of Heat, Migration, and Inflammation

Speaker Karen Chang

Track Cellular Adhesion, Migration, and Inflammation (CAM)

Year 2026

Keywords

integrins

memory B cells

allergic asthma

IgE responses

VCAM1 ICAM1

April 17, 2026 10:30 AM - 10:45 AM

102

Lymphocyte and Innate Leukocyte Mastery of Heat, Migration, and Inflammation

Karen Chang

Cellular Adhesion, Migration, and Inflammation (CAM)

2026