IMMUNOLOGY2026™ Conference Recordings For Attendees-Interrelationship of Peritoneal Fluid and Mesothelial Macrophages and Species-Specific Pathways in Their Maintenance and Repopulation

Interrelationship of Peritoneal Fluid and Mesothelial Macrophages and Species-Specific Pathways in Their Maintenance and Repopulation

Back to course

Video Transcription

Video Summary

This talk focused on the origin and differentiation of large peritoneal macrophages (LCMs), immune cells in the fluid-filled peritoneal cavity, a key site for inflammation and cancers such as ovarian, gastric, and colorectal metastasis. Although mouse studies suggested a single differentiation path to mature GATA6-positive LCMs, human samples showed many LIV1+ CD206+ cells, raising questions about species differences. Using high-parameter flow cytometry and multiple mouse lineage-tracing models, the speaker identified two LCM precursor pathways. One route passes through a LIV1+ intermediate and depends on the ZEB2 enhancer, resembling the human pathway. A second, mouse-specific route generates mature LCMs directly, independent of that enhancer. The work suggests the peritoneal cavity contains distinct macrophage lineages shaped by local niches, including the mesothelial lining, with potential relevance to peritoneal metastasis and other border tissues.

Meta Tag

Date April 16, 2026 4:45 PM - 5:00 PM

Room 104AB

Session Bone Marrow Hematopoiesis

Speaker Jichang Han

Track Hematopoiesis and Immune System Development (HEM)

Year 2026

Keywords

large peritoneal macrophages

LCM differentiation

LIV1+ CD206+ cells

ZEB2 enhancer

peritoneal metastasis

April 16, 2026 4:45 PM - 5:00 PM

104AB

Bone Marrow Hematopoiesis

Jichang Han

Hematopoiesis and Immune System Development (HEM)

2026