IMMUNOLOGY2026™ Conference Recordings For Attendees-Introduction: 20 Years of Th17 Cells: Discovery and Clinical Impact

Introduction: 20 Years of Th17 Cells: Discovery and Clinical Impact

Video Transcription

Video Summary

The speaker traces the discovery of Th17 cells from early Th1/Th2 concepts to the realization that IL-23, not IL-12, drives autoimmune inflammation. Key milestones included identifying IL-17-producing T cells, defining differentiation signals like TGF-beta plus IL-6 or IL-21, and discovering the transcription factor RORγt. Th17 cells produce IL-17, IL-21, and IL-22 and are important in tissue inflammation, fungal defense, psoriasis, IBD, and possibly MS. The talk also highlights how IL-23 promotes pathogenicity and how anti-IL-17 and anti-IL-23 therapies have become effective treatments.

Meta Tag

Date April 18, 2026 8:00 AM - 8:10 AM

Room Ballroom

Session Major Symposium F: 20 Years of Th17 Cells: Discovery and Clinical Impact

Speaker Vijay Kuchroo

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

Th17 cells

IL-23

IL-17

RORγt

autoimmune inflammation

April 18, 2026 8:00 AM - 8:10 AM

Ballroom

Major Symposium F: 20 Years of Th17 Cells: Discovery and Clinical Impact

Vijay Kuchroo

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026