IMMUNOLOGY2026™ Conference Recordings For Attendees-Investigating the role of Dectin-1 in the host immune responses to Schistosoma mansoni cercariae in acute schistosomiasis

Investigating the role of Dectin-1 in the host immune responses to Schistosoma mansoni cercariae in acute schistosomiasis

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Megan presented research on acute schistosomiasis, a neglected tropical disease caused by Schistosoma mansoni. Her lab is investigating how the immune receptor Dectin-1 senses cercarial parasite components and drives inflammation. Using macrophages, they found that insoluble cercarial material specifically triggered IL-1 production. Experiments showed Dectin-1 promotes this response through SYK, NLRP3, and caspase-8 signaling, while reducing IL-10. Inhibiting Dectin-1, SYK, NLRP3, or caspase-8 reduced IL-1 secretion. The work suggests Dectin-1 detects a parasite-derived insoluble component, possibly from the tegument, and helps shape inflammatory responses in early schistosomiasis.

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Date April 16, 2026 3:57 PM - 4:09 PM

Room 156

Session Pathogen Sensing and Innate Immune Responses

Speaker Megan Nitchman

Track Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

Year 2026

Keywords

acute schistosomiasis

Schistosoma mansoni

Dectin-1 signaling

IL-1 inflammation

NLRP3 caspase-8

April 16, 2026 3:57 PM - 4:09 PM

156

Pathogen Sensing and Innate Immune Responses

Megan Nitchman

Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

2026