IMMUNOLOGY2026™ Conference Recordings For Attendees-Iron metabolism In Dendritic Cells is important for Induction of Follicular Helper T Cell Subsets in Allergy

Iron metabolism In Dendritic Cells is important for Induction of Follicular Helper T Cell Subsets in Allergy

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Video Summary

Parth Naik presented research on how iron metabolism in dendritic cells affects allergic asthma. Asthma involves allergen-driven immune responses that lead dendritic cells to activate naive T cells, especially follicular helper T cells (TFH), which support B cells in producing IgE and other antibodies. His data showed that asthmatic conditions alter ion-handling genes in dendritic cells, including iron transport pathways. <br /><br />Using two iron-blocking approaches—peristaltin 2, which inhibits iron import, and deferiprone, an iron chelator—he found a specific loss of TFH13 cells, while TFH2, TH2, Tregs, and TFRs were largely unchanged. Blocking iron also reduced IgG1-positive germinal center B cells and IgG1 plasma cells. He further identified a CD71-high dendritic cell subset in allergic models, suggesting these cells may help drive TFH13 polarization. Overall, the work suggests iron availability in dendritic cells is important for generating TFH13 responses in asthma.

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Date April 17, 2026 5:15 PM - 5:30 PM

Room 205

Session Airway Hypersensitivity and Asthma

Speaker Parth Naik

Track Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

Year 2026

Keywords

iron metabolism

dendritic cells

allergic asthma

TFH13 cells

CD71-high dendritic cells

April 17, 2026 5:15 PM - 5:30 PM

205

Airway Hypersensitivity and Asthma

Parth Naik

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

2026