IMMUNOLOGY2026™ Conference Recordings For Attendees-KDM5C-regulated anabolic metabolism is required for T cell expansion

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Video Summary

The speaker described research on KDM5C, an X-linked histone demethylase that is induced during T-cell activation and other states of high anabolic demand. In T cells, KDM5C helps support clonal expansion and effective antiviral responses. Mice lacking KDM5C showed poorer clearance of LCMV infection, fewer antigen-specific T cells, higher PD-1, and reduced polyfunctionality. RNA-seq and metabolomics revealed that KDM5C deficiency mainly disrupts anabolic metabolism rather than mitochondrial programs, with decreased nucleotide and fatty acid biosynthesis. The defect was linked to lower expression of ACC1, SREBP pathway genes, and other lipogenic regulators. KDM5C binds promoters of anabolic genes and appears to sustain their expression in a demethylase-independent manner, likely maintaining the metabolic program after transient TCR/mTOR signaling fades. The discussion highlighted possible links to transcription factor interactions, metabolite sensing, and antigen presentation in dendritic cells.

Meta Tag

Date April 16, 2026 9:45 AM - 10:00 AM

Room 153AB

Session Epigenetics and Post-Transcriptional Regulation

Speaker Connie Krawczyk

Track Immune Response Regulation: Molecular Mechanisms (IRM)

Year 2026

Keywords

KDM5C

T-cell activation

anabolic metabolism

antiviral immunity

histone demethylase

April 16, 2026 9:45 AM - 10:00 AM

153AB

Epigenetics and Post-Transcriptional Regulation

Connie Krawczyk

Immune Response Regulation: Molecular Mechanisms (IRM)

2026