IMMUNOLOGY2026™ Conference Recordings For Attendees-LOX-1 promotes efferocytosis and oxLDL-mediated immune reprogramming of alveolar macrophages during pneumonia.

LOX-1 promotes efferocytosis and oxLDL-mediated immune reprogramming of alveolar macrophages during pneumonia.

Video Transcription

Video Summary

The speaker introduced research on alveolar macrophages, pneumonia, and the scavenger receptor LOX1. Pneumonia causes major infection-related mortality, and current treatments are limited because many pathogens can cause it and host-driven lung inflammation also contributes to damage. The lab found that oxidized LDL and LOX1 increase in infected lungs and human ARDS samples. Blocking LOX1 with an antibody worsened lung injury, inflammation, and survival in mice, while macrophage-specific LOX1 knockout also increased injury, suggesting LOX1 protects the lung. LOX1 appears to reduce inflammation partly by promoting macrophage efferocytosis, the clearance of dying cells. The lab also showed that oxidized LDL can “train” alveolar macrophages, changing their phenotype and influencing neutrophils during later infection, though the consequences for pathogen clearance and injury are still being studied.

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Date April 17, 2026 4:30 PM - 4:45 PM

Room 153C

Session Signaling Pathways Modulating Immune Responses to Microbial Infections

Speaker Filiz Korkmaz

Track Microbial, Parasitic, and Fungal Immunology (MPF)

Year 2026

Keywords

alveolar macrophages

pneumonia

LOX1

efferocytosis

oxidized LDL

April 17, 2026 4:30 PM - 4:45 PM

153C

Signaling Pathways Modulating Immune Responses to Microbial Infections

Filiz Korkmaz

Microbial, Parasitic, and Fungal Immunology (MPF)

2026