IMMUNOLOGY2026™ Conference Recordings For Attendees-Lactate modulation of macrophage function in inflammation and resolution

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Video Summary

The speaker presented research on intestinal macrophages in inflammatory bowel disease (IBD), focusing on how lactate helps resolve inflammation. In IBD patients, colonic lactate levels and the lactate transporter MCT1 were reduced, especially in ulcerative colitis. In mouse DSS colitis models, lactate worsened inflammation, but this effect depended on macrophages and was linked to reduced efferocytosis, the clearing of apoptotic cells.<br /><br />The key mechanism involved the “do-not-eat-me” receptor SIRPα. Lactate suppresses SIRPα expression by reducing a SIRPα enhancer RNA (eRNA). This eRNA is stabilized by METTL3-mediated m6A modification; when m6A is reduced, SIRPα rises and efferocytosis declines. Blocking the eRNA with antisense oligonucleotides or inhibiting SIRPα improved colitis and increased pro-resolving macrophages. Overall, the study suggests lactate promotes inflammation resolution by controlling epigenetic regulation of macrophage efferocytosis, offering possible therapeutic targets for IBD.

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Date April 18, 2026 10:03 AM - 10:21 AM

Room 153C

Session A New Era in Interdisciplinary Immunotherapy, Sponsored by the Chinese Soc. for Immunol. (CSI)

Speaker Qingqing Wang

Track Translational and Interventional Immunology (TI)

Year 2026

Keywords

inflammatory bowel disease

intestinal macrophages

lactate

SIRPα

efferocytosis

April 18, 2026 10:03 AM - 10:21 AM

153C

A New Era in Interdisciplinary Immunotherapy, Sponsored by the Chinese Soc. for Immunol. (CSI)

Qingqing Wang

Translational and Interventional Immunology (TI)

2026