IMMUNOLOGY2026™ Conference Recordings For Attendees-Local immune networks promote respiratory IgA responses after mucosal vaccination

Local immune networks promote respiratory IgA responses after mucosal vaccination

Video Transcription

Video Summary

Jinyi Tang presented work showing that respiratory IgA is strongly boosted by mucosal vaccination plus infection, especially with an adenovirus-based mucosal booster. In mice, this approach generated the highest lung IgA, IgA B cells, and protection against virus, and protection depended on IgA. He found local CD4 T cells in the respiratory tract help drive IgA class switching, B-cell proliferation, and plasma cell formation through MHC II, ICOS, and IL-21 signaling. The key helper cells were Th1-like, especially Bcl-1/Blimp-1–associated terminal effector CD4 T cells. The model suggests local immune cell interactions promote durable respiratory mucosal immunity.

Meta Tag

Date April 15, 2026 3:30 PM - 3:45 PM

Room 102

Session Immunology of the Respiratory Tract

Speaker Jinyi Tang

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

respiratory IgA

mucosal vaccination

adenovirus booster

CD4 T cells

mucosal immunity

April 15, 2026 3:30 PM - 3:45 PM

102

Immunology of the Respiratory Tract

Jinyi Tang

Mucosal And Regional Immunology (MUC)

2026