IMMUNOLOGY2026™ Conference Recordings For Attendees-Loss of the Y chromosome evokes extrinsic extramedullary myelopoiesis via genome-wide epigenetic reprogramming of bladder cancer tumor cells

Loss of the Y chromosome evokes extrinsic extramedullary myelopoiesis via genome-wide epigenetic reprogramming of bladder cancer tumor cells

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Video Summary

The speaker explains why the Y chromosome matters in cancer and aging, noting that about half of men over 70 lose it in many cells, and that this loss is linked to cancer, dementia, heart disease, and immune dysfunction. Focusing on bladder cancer, the study shows that Y chromosome loss is associated with increased macrophage infiltration, worse survival, and faster tumor growth. In mouse models, Y-loss tumors attracted splenic monocytes that became suppressive macrophages, which shut down CD8 T-cell activity and promoted tumor progression. The team identified a feed-forward chemokine loop involving CCR2 and CCL12, and traced the effect to loss of Y-linked genes UTY and KDM5D. This caused epigenetic changes that upregulated CD13, a soluble factor responsible for much of the immune and tumor-promoting phenotype. Blocking macrophages, CCR2, or CD13 reduced tumor growth.

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Date April 19, 2026 8:45 AM - 9:00 AM

Room 156

Session Immune Cells in the Tumor Microenvironment II

Speaker Jay Mandula

Track Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

Year 2026

Keywords

Y chromosome loss

bladder cancer

macrophage infiltration

CCR2 CCL12 loop

CD13

April 19, 2026 8:45 AM - 9:00 AM

156

Immune Cells in the Tumor Microenvironment II

Jay Mandula

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

2026