IMMUNOLOGY2026™ Conference Recordings For Attendees-Loss of the microbiota unleashes harmful T cell responses against dietary antigen induced by enteric viruses

Loss of the microbiota unleashes harmful T cell responses against dietary antigen induced by enteric viruses

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Video Summary

Nick from the Jobry Lab presented research linking early-life viral infection and microbiota disruption to celiac disease risk. In a mouse oral tolerance model, viral infection at the time a new dietary antigen is introduced shifts T cells away from regulatory T cells and toward a Th1 inflammatory fate. His group found that antibiotics or germ-free conditions усилify this Th1 response during reovirus or gliadin exposure. The effect depends on migratory dendritic cells, likely CDC2B cells, rather than classical DC1s. On the microbial side, short-chain fatty acids produced by gut bacteria suppress the Th1 shift through GPR signaling; restoring these signals with bacterial consortia or GPR agonists reduced the inflammatory response. Overall, the work suggests that gut viruses and microbiota compete to shape early immune priming to dietary antigens, with implications for celiac disease development.

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Date April 17, 2026 12:45 PM - 1:00 PM

Room 153AB

Session T Cell Responses to the Gut Microbiota

Speaker Nicholas Usher

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

celiac disease

viral infection

microbiota disruption

Th1 inflammatory response

short-chain fatty acids

April 17, 2026 12:45 PM - 1:00 PM

153AB

T Cell Responses to the Gut Microbiota

Nicholas Usher

Mucosal And Regional Immunology (MUC)

2026