IMMUNOLOGY2026™ Conference Recordings For Attendees-Lung Tfh13 Differentiate from Lymph Node-derived Progenitor Tfh Cells to Sustain Allergic Antibody Responses

Lung Tfh13 Differentiate from Lymph Node-derived Progenitor Tfh Cells to Sustain Allergic Antibody Responses

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Video Summary

The talk examined how allergic antibody responses are sustained in acute and chronic lung allergy. The speaker described TFH13 cells, a subset of T follicular helper cells that produce IL-13 and help drive pathogenic IgE/IgG responses. Using fate-mapping and conditional deletion mice, the team showed that TFH13 cells are rare in acute draining lymph nodes but are essential for germinal center activity and allergy-associated antibodies. In chronic lung allergy, TFH13 cells became much more abundant in the lung, arising from TFH progenitors that first express IL-21 and later switch toward a TH2-like, IL-13-producing state. Single-cell and spatial analyses revealed these cells localize near IL-33-producing stromal cells and express ST2, the IL-33 receptor. IL-33 promoted TFH13 differentiation and proliferation in vitro and in vivo. Overall, the study shows an IL-33–ST2 axis helps recruit and maintain TFH13 cells in lung tissue, sustaining chronic allergic inflammation and antibody production.

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Date April 17, 2026 4:30 PM - 4:45 PM

Room 205

Session Airway Hypersensitivity and Asthma

Speaker Pragya Chandrakar

Track Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

Year 2026

Keywords

TFH13 cells

IL-33 ST2 axis

chronic lung allergy

IgE IgG responses

germinal center activity

April 17, 2026 4:30 PM - 4:45 PM

205

Airway Hypersensitivity and Asthma

Pragya Chandrakar

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

2026