IMMUNOLOGY2026™ Conference Recordings For Attendees-Male-Biased Macrophage Signaling and CD8 T Cell Dysfunction Drive Immunosuppression in Pulmonary Fibrosis

Male-Biased Macrophage Signaling and CD8 T Cell Dysfunction Drive Immunosuppression in Pulmonary Fibrosis

Video Transcription

Video Summary

The speaker explains pulmonary fibrosis as progressive lung scarring that blocks oxygen exchange and has poor survival with no cure. Their research suggests males are more severely affected than females. Using lung slices, mice, blood RNA sequencing, and single-cell analysis, they found male lungs show more collagen, worse survival, and stronger pro-fibrotic immune signals. In males, alveolar cells, fibroblasts, macrophages, and CD8 T cells behave abnormally: repair fails, fibroblasts proliferate, macrophages become pro-fibrotic and suppressive, and T cells are dysfunctional. The talk concludes that sex-based immune differences may help explain disease severity and guide targeted therapies.

Meta Tag

Date April 18, 2026 8:00 AM - 8:15 AM

Room 104AB

Session Tissue and Mucosal Immunity

Speaker John Vang

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

pulmonary fibrosis

lung scarring

sex differences

pro-fibrotic immune signals

single-cell analysis

April 18, 2026 8:00 AM - 8:15 AM

104AB

Tissue and Mucosal Immunity

John Vang

Immune Mechanisms of Human Disease (HUM)

2026