IMMUNOLOGY2026™ Conference Recordings For Attendees-Mammary tumour hijacking of myelopoiesis

Video Transcription

Video Summary

Hannah described work showing that mammary tumors systemically reprogram the bone marrow, starting at the level of long-term hematopoietic stem cells. In both metastatic breast cancer patients and a mouse mammary tumor model (KEP), tumors caused increased circulating neutrophils with enhanced nitric oxide and ROS production, making them more suppressive of T cell proliferation and more supportive of metastasis. Single-cell and bulk RNA-seq revealed that tumor-bearing mice had more myeloid progenitors and fewer lymphoid/erythroid progenitors, with stem cells pushed toward accelerated neutrophil differentiation. IL-1β emerged as a key driver: HSPCs express IL-1R1, respond directly to IL-1β, and anti-IL-1β treatment normalized transcriptional and chromatin changes, reduced suppressive neutrophil function, and lowered lung and lymph node metastasis. The team is now testing combination therapy with checkpoint blockade in established metastatic disease.

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Date April 19, 2026 8:00 AM - 9:30 AM

Room 153C

Session Remember Me! - Exploration of the full spectrum of immune memory, Sponsored by the Canadian Society of Immunology (CSI)

Speaker Hannah Garner

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

April 19, 2026 8:00 AM - 9:30 AM

153C

Remember Me! - Exploration of the full spectrum of immune memory, Sponsored by the Canadian Society of Immunology (CSI)

Hannah Garner

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026

mammary tumors

bone marrow reprogramming

IL-1β

neutrophils

metastasis

hematopoietic stem cells