IMMUNOLOGY2026™ Conference Recordings For Attendees-Meningeal lymphoid hubs support autoreactive immune responses

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Video Summary

The speaker described a newly identified meningeal immune structure called the rostro-renal veno-lymphatic hub, located near fenestrated venous plexuses at the base of the skull. This hub contains immune cells, lymphatic vessels, and leaky blood vessels, making it a key site for immune surveillance but also a potential entry point for pathogens. After nasal vesicular stomatitis virus infection, the hub mounted strong antiviral germinal center responses. The talk then focused on spontaneous meningeal immune clusters involved in self-reactivity. These clusters required MHC class II, CD4 T cells, and adaptive immunity, but not gut microbiota. Myelin debris accumulated especially in the hub, likely due to leaky olfactory barriers and fenestrated vessels. Myelin-specific T cells localized there early and interacted with B cells. Depleting B cells increased myelin accumulation, worsened EAE, and reduced survival, indicating a regulatory, protective B-cell role in maintaining tolerance to self-antigens.

Meta Tag

Date April 18, 2026 9:15 AM - 9:30 AM

Room 157

Session Neurodegenerative & Autoimmune Disorders

Speaker Nagela Ghabdan Zanluqui

Track Neuroimmunology (NEUR)

Year 2026

Keywords

rostro-renal veno-lymphatic hub

meningeal immune structure

germinal center response

myelin-specific T cells

B cell tolerance

April 18, 2026 9:15 AM - 9:30 AM

157

Neurodegenerative & Autoimmune Disorders

Nagela Ghabdan Zanluqui

Neuroimmunology (NEUR)

2026