IMMUNOLOGY2026™ Conference Recordings For Attendees-Methionine metabolism shapes epigenetic and functional programs of developing CD8+ T cells

Methionine metabolism shapes epigenetic and functional programs of developing CD8+ T cells

Video Transcription

Video Summary

Dr. Daniela Vega-Mendoza showed that neonatal CD8 T cells are programmed for rapid effector responses but weaker long-term memory. Her work links methionine metabolism to epigenetic control, especially H3K4 trimethylation and the transcription factor Helios. Neonatal cells depend more on methionine/SAM availability to induce Helios, shaping their fate after infection. Similar, though less pronounced, effects were seen in human neonatal cells. In a Listeria model, Helios marked effector-precursor-like neonatal CD8 T cells. Overall, methionine metabolism helps drive distinct neonatal CD8 T-cell programs and may influence vaccine responses and immunity early in life.

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Date April 15, 2026 4:30 PM - 4:45 PM

Room 153AB

Session T Cell Development

Speaker Daniela Vega-Mendoza

Track Hematopoiesis and Immune System Development (HEM)

Year 2026

Keywords

neonatal CD8 T cells

methionine metabolism

Helios transcription factor

H3K4 trimethylation

vaccine responses

April 15, 2026 4:30 PM - 4:45 PM

153AB

T Cell Development

Daniela Vega-Mendoza

Hematopoiesis and Immune System Development (HEM)

2026