IMMUNOLOGY2026™ Conference Recordings For Attendees-Microbiota-dependent Interferon Lambda Controls Uterine Immunity and Placental Anti-bacterial Responses

Microbiota-dependent Interferon Lambda Controls Uterine Immunity and Placental Anti-bacterial Responses

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Video Summary

The talk explored how vaginal microbiota, especially group B strep products, shape uterine immunity. In mice, microbiota increased type 1 and especially type 17 immune cells, even without live bacteria. The speaker found interferon lambda acts as a brake on this response by limiting inflammatory cytokines from epithelial and dendritic cells. During pregnancy, interferon lambda also protected the maternal-fetal interface from ascending GBS infection and reduced fetal transmission and neonatal infection. Overall, interferon lambda appears to be an important regulator of uterine immune balance and a previously underappreciated antibacterial factor in pregnancy.

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Date April 17, 2026 4:45 PM - 5:00 PM

Room 253

Session Regulation of Immunity and Inflammation in the Genital Tract

Speaker Elisha Segrist

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

vaginal microbiota

group B strep

uterine immunity

interferon lambda

pregnancy infection protection

April 17, 2026 4:45 PM - 5:00 PM

253

Regulation of Immunity and Inflammation in the Genital Tract

Elisha Segrist

Mucosal And Regional Immunology (MUC)

2026