IMMUNOLOGY2026™ Conference Recordings For Attendees-Microglial Remodeling of Cerebrovascular Structure and Function during Respiratory Inflammation

Microglial Remodeling of Cerebrovascular Structure and Function during Respiratory Inflammation

Video Transcription

Video Summary

Osari Lawani presented research on how microglia, the brain’s resident immune cells, respond to respiratory infection. Using intertracheal LPS in mice, the lab found increased capillary-associated microglia and more CD68-positive activated microglia, while total microglial numbers stayed stable. P2RY12 decreased over time, suggesting progressive activation. Vascular analysis showed no change in capillary diameter, but cerebral blood flow decreased after LPS. Preliminary FIRE mouse experiments suggested microglia may be important for sickness behavior, since microglia-deficient mice lacked weight loss. Overall, microglia may help drive immune and vascular changes during respiratory inflammation.

Meta Tag

Date April 18, 2026 10:57 AM - 11:09 AM

Room 104AB

Session Immunity at CNS Barriers and Borders

Speaker Osaretin Lawani

Track Neuroimmunology (NEUR)

Year 2026

Keywords

microglia

respiratory infection

LPS

cerebral blood flow

sickness behavior

April 18, 2026 10:57 AM - 11:09 AM

104AB

Immunity at CNS Barriers and Borders

Osaretin Lawani

Neuroimmunology (NEUR)

2026