IMMUNOLOGY2026™ Conference Recordings For Attendees-Modelling of early-life immunity shaped by contrasting environments

Modelling of early-life immunity shaped by contrasting environments

Video Transcription

Video Summary

Florenz Lohmann presented a multi-cohort study of early-life immune development across urban European and rural African settings. Using targeted proteomics on nearly 600 children and 2,600 blood samples, he found that both age and environment strongly shape immune trajectories. Some protein changes were conserved across locations, but many differed by setting and were detectable by six weeks. European cohorts showed an early Th2 skew, while African cohorts showed Th1 patterns. Early antibiotic exposure was linked to persistent inflammatory signals and possible accelerated immune maturation, though conclusions are limited by confounding factors like geography, nutrition, genetics, and cohort differences.

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Date April 18, 2026 8:15 AM - 8:30 AM

Room 104AB

Session Tissue and Mucosal Immunity

Speaker Florens Lohrmann

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

early-life immune development

targeted proteomics

Th2 skew

Th1 patterns

antibiotic exposure

April 18, 2026 8:15 AM - 8:30 AM

104AB

Tissue and Mucosal Immunity

Florens Lohrmann

Immune Mechanisms of Human Disease (HUM)

2026