IMMUNOLOGY2026™ Conference Recordings For Attendees-Modular Evaluation of Multi-Platform Human In vitro Systems (MEMPHIS): A Methodological Advancement in Vaccinology

Modular Evaluation of Multi-Platform Human In vitro Systems (MEMPHIS): A Methodological Advancement in Vaccinology

Video Transcription

Video Summary

The speaker presented MEMPHIS, a modular human in vitro platform for evaluating vaccine adjuvants and immune responses without relying solely on animal models. Using assays with whole blood, dendritic cells, T cells, B cells, and tissue constructs, the platform measures innate activation, T-cell polarization, baseline immunity, and B-cell memory while using minimal blood volumes. Results showed age-specific differences: adults and children responded differently, with children displaying greater baseline heterogeneity. The platform identified how MPLA and QS21, alone or combined in liposomal or oil-in-water formulations, influenced cytokine production and antigen-specific CD4/CD8 T-cell responses in adults and children. Cross-platform integration and multi-omic analysis were used to correlate immune signatures with age and adjuvant effects, helping rank adjuvant candidates for future clinical trials. The work aims to improve vaccine design by predicting potency, reactogenicity, breadth, and durability across populations.

Meta Tag

Date April 16, 2026 1:00 PM - 1:15 PM

Room 205

Session Innovations in Bench Techniques

Speaker Sanya Thomas

Track Technological Innovations in Immunology (TECH)

Year 2026

Keywords

MEMPHIS

vaccine adjuvants

immune responses

T-cell polarization

age-specific immunity

April 16, 2026 1:00 PM - 1:15 PM

205

Innovations in Bench Techniques

Sanya Thomas

Technological Innovations in Immunology (TECH)

2026