IMMUNOLOGY2026™ Conference Recordings For Attendees-Monocyte-Derived ADA2 Regulates Myeloid-T Cell Crosstalk and Drives Pro-Inflammatory Responses Linked with Intestinal Inflammation in Crohn's Disease

Monocyte-Derived ADA2 Regulates Myeloid-T Cell Crosstalk and Drives Pro-Inflammatory Responses Linked with Intestinal Inflammation in Crohn's Disease

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The speaker presented research on ADA2, an enzyme secreted by activated monocytes and macrophages that converts adenosine to inosine, and may shape inflammation in Crohn’s disease. Because adenosine is anti-inflammatory, the team investigated whether ADA2 promotes pro-inflammatory immune responses in inflamed gut tissue. In Crohn’s patients, ADA2 activity was elevated in serum and inflamed intestinal tissue, while intracellular ADA2 levels were reduced, suggesting a compartment shift. ADA2-positive monocytes in inflamed tissue showed pro-inflammatory features, including higher TNF, IL-6, IFN-γ, and IL-23, and were associated with CXCR3 expression. In vitro, ADA2-treated macrophages became more inflammatory and induced TH17-like T cell responses. Overall, the study proposes that monocyte-derived ADA2 drives myeloid–T cell crosstalk through the IL-23/IL-17 axis, contributing to Crohn’s disease inflammation and potentially explaining why some patients remain unresponsive to current therapies.

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Date April 15, 2026 4:00 PM - 4:15 PM

Room 157

Session Orchestration of the Adaptive Immune Response

Speaker Silpa Tiwari-Heckler

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

ADA2

Crohn's disease

monocytes

IL-23/IL-17 axis

inflammation

April 15, 2026 4:00 PM - 4:15 PM

157

Orchestration of the Adaptive Immune Response

Silpa Tiwari-Heckler

Immune Mechanisms of Human Disease (HUM)

2026