IMMUNOLOGY2026™ Conference Recordings For Attendees-Morning influenza vaccination elicits superior antigen-specific immune responses in adults aged 60-85 years

Morning influenza vaccination elicits superior antigen-specific immune responses in adults aged 60-85 years

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Video Summary

Tamara Brouwers presented the HONOVAX randomized controlled trial testing whether influenza vaccination timing affects immune responses in older adults (ages 60–85). Because immune function follows circadian rhythms, the study compared morning, early afternoon, and late afternoon vaccination, and also analyzed exact vaccination time and timing relative to each person’s chronotype. In 278 participants, morning vaccination produced the strongest antibody responses and generally the best T-cell responses, with peak effects around 9 a.m. When adjusted for chronotype, the best responses occurred early in each person’s biological day, suggesting that “morning” may depend on whether someone is an early or late type. The findings suggest that scheduling flu shots earlier in the day could be a simple, safe way to improve vaccine immunogenicity in older adults, potentially complementing other strategies like high-dose or adjuvanted vaccines.

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Date April 16, 2026 10:45 AM - 11:00 AM

Room 156

Session Understanding Immune Responses to Optimize Immune Intervention

Speaker Tamara Brouwers

Track Translational and Interventional Immunology (TI)

Year 2026

Keywords

influenza vaccination timing

older adults

immune response

chronotype

morning vaccination

April 16, 2026 10:45 AM - 11:00 AM

156

Understanding Immune Responses to Optimize Immune Intervention

Tamara Brouwers

Translational and Interventional Immunology (TI)

2026