IMMUNOLOGY2026™ Conference Recordings For Attendees-Multi-omics profiling with InTraSeq™ uncovers novel single-cell RNA and Proteomics events in CARTs

Multi-omics profiling with InTraSeq™ uncovers novel single-cell RNA and Proteomics events in CARTs

Video Transcription

Video Summary

Anis presented a new, more controlled way to naturalize laboratory mice with complex, pet-store-derived microbiota. By collecting large, anaerobically processed cecal samples and biobanking them with high viability, the team created standardized “stocks” that can be given to SPF mice of different ages, sexes, and genotypes. The approach produced consistent microbial communities across batches and expanded not just bacteria, but also viruses, fungi, and parasites.  <br /><br />Using this platform, they built a deep immune resource showing durable immune maturation: early inflammation led to long-lasting changes in bone marrow, B cells, T follicular helper cells, and tissue-resident T cells in organs beyond the gut. Their single-cell atlas identified 70 immune subsets and revealed female-biased interferon signatures and a female-enriched T-cell population linked to human autoimmune signatures.  <br /><br />They also showed the model better captures bystander T-cell activation, with male-biased responses relevant to inflammatory pathology.

Meta Tag

Date April 18, 2026 2:00 PM - 2:15 PM

Room 151

Session Technical Innovations for Therapies

Speaker Majd Ariss

Track Technological Innovations in Immunology (TECH)

Year 2026

Keywords

laboratory mice

microbiota naturalization

immune maturation

single-cell atlas

T-cell activation

April 18, 2026 2:00 PM - 2:15 PM

151

Technical Innovations for Therapies

Majd Ariss

Technological Innovations in Immunology (TECH)

2026