IMMUNOLOGY2026™ Conference Recordings For Attendees-Multicellular Control of T cell Responses

Video Transcription

Video Summary

Eric Guy presented a model for T cell immune control based on “activation density” rather than single-cell TCR avidity alone. He argued that self-reactive T cells persist in the mature repertoire, so the immune system must regulate responses at the multicellular level. Using mouse skin immunization and optical clearing/confocal imaging of lymph nodes, he visualized migratory antigen-presenting cells, regulatory T cells, and conventional T cell activation. By comparing immunogens with limited peptide diversity (OVA) versus broad peptide diversity (KLH), he found that KLH created local hotspots of activated T cells around antigen-presenting cells. These dense regions were associated with higher CMIC, a marker of integrated activation signaling. The work suggests that stronger local T cell clustering promotes productive responses to non-self, while regulatory T cells help suppress self-reactive responses. Discussion covered possible roles for naive repertoire differences, persistent TCR stimulation, and Treg mobility in shaping this boundary.

Meta Tag

Date April 19, 2026 8:00 AM - 8:15 AM

Room 153AB

Session Dynamic Control of T Cell Activation

Speaker Eric Gai

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

T cell immune control

activation density

antigen-presenting cells

regulatory T cells

lymph node imaging

April 19, 2026 8:00 AM - 8:15 AM

153AB

Dynamic Control of T Cell Activation

Eric Gai

Immune Response Regulation: Cellular Mechanisms (IRC)

2026